Welcome to your August newsletter.
Hi, I hope you enjoy your August newsletter, here in the northern hemisphere we are well into summer and hope that if you've been lucky enough to get out in the sunshine it has helped your psoriasis. Has the worry of covid-19 made you nervous and affected your psoriasis and ability to be outside or has it remained the same during lockdown. I myself am far more nervous now than I was at the start of the outbreak, mainly because the easing of restrictions has sent everyone out socialising again and where it was contained it seems as if lots of people aren't taking the rules seriously.
Have you or any of your family had it and if so how did it affect you. We would love to hear as although there has been a lot of talk on the forum about it we haven't had anyone telling of their experience.
If you would like to start a thread about your experiences what better time to come in and do it and relate it to your psoriasis experience Here.
The off topic has been as busy as ever and games and quiz board is proving very popular . Why not pop in and have a bit of fun. Games and Quizzes Here.
If you're a guest feel free to browse through the links here and join if you want to see more. Some off topic items may not be available for guests but all the health boards are.
The forum team have been busy keeping an eye on the Club and are there for you, so if you can't find something you are looking for or if you aren't sure how to do something, we are here to help just click the link below to make contact HERE.
If you are currently a subscriber to the newsletter you will receive notification with a link at the beginning of each month. If you don't currently recieve one and would like to receive an email when a new newsletter is made click HERE.
Note: Subscribed members get an early view of the newsletter.
Cosentyx gets positive opinion from (CHMP) for use with Psoriasis in Children
Cosentyx could soon be prescribed for children
Novartis announced the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has adopted a positive opinion for Cosentyx® (secukinumab) for the treatment of moderate-to-severe plaque psoriasis in children and adolescents aged 6 to 18 years.
“Psoriasis affects children much deeper than just the skin and can lead to deterioration of quality of life, potentially having a lasting impact on this vulnerable patient population,” said Todd Fox, Global Head of Medical Affairs Immunology, Hepatology and Dermatology at Novartis. “This is our second positive CHMP opinion for Cosentyx this year alone, following on from recent EC approval in nr-axSpA. The latest positive opinion is an important step forward in our commitment to reimagining care for children with psoriasis, giving them freedom to enjoy full and active lives.”
The positive CHMP opinion is based on two Phase III international studies in children and adolescents aged 6 to 18 years, one open‑label, two-arm, parallel‑group, multicentre study with moderate-to-severe plaque psoriasis and one randomized, double-blind, placebo and etanercept-controlled study with severe plaque psoriasis. The studies showed both low-dose (75–150 mg) and high-dose (75–300 mg) of Cosentyx were highly efficacious in rapidly improving skin symptoms and quality of life, with a favorable safety profile up to 52 weeks. read more here
Tremfya gets FDA approval for psoriatic arthritis
Janssen announced that the U.S. Food and Drug Administration (FDA) has approved TREMFYA® (guselkumab) for adult patients with active psoriatic arthritis (PsA), a chronic progressive disease characterized by painful joints and skin inflammation. TREMFYA is the first treatment approved for active PsA that selectively inhibits interleukin (IL)-23, a naturally occurring cytokine that is involved in normal inflammatory and immune responses associated with the symptoms of PsA. The safety and efficacy of TREMFYA in PsA have been demonstrated in two pivotal Phase 3 clinical trials. TREMFYA is administered as a 100 mg subcutaneous injection every eight weeks, following two starter doses at weeks 0 and 4. TREMFYA can be used alone or in combination with a conventional Disease Modifying Anti-Rheumatic Drug or DMARD (e.g., methotrexate). read more here
Wynzora gets FDA approval for plaque psoriasis
MC2 Therapeutics have announced that they have received U.S. Food and Drug Administration (FDA) approval for the use of Wynzora Cream (calcipotriene and betamethasone dipropionate, w/w 0.005%/0.064%) for once-daily topical treatment of plaque psoriasis in adults 18 years of age or older.
MC2 Therapeutics, a commercial stage pharmaceutical company developing a new standard of topical therapies for chronic inflammatory conditions, announced today that the U.S. Food and Drug Administration (FDA) has approved Wynzora Cream (calcipotriene and betamethasone dipropionate, w/w 0.005%/0.064%) for once-daily topical treatment of plaque psoriasis in adults 18 years of age or older.
The FDA approval is based on the results of the US Phase 3 clinical trial against active comparator Taclonex Topical Suspension (calcipotriene and betamethasone dipropionate, w/w 0.005%/0.064%). A total of 794 patients were randomized in this trial and the primary efficacy endpoint was the proportion of patients with PGA treatment success at week 8 defined as at least a 2-grade improvement from baseline in PGA to “clear” or “almost clear”. The difference in PGA treatment success to the active comparator was 14.6% (95% CI; 7.6%, 21.6%) in favor of Wynzora Cream. Read more here
Bimekizumab beats Cosentyx in skin clearance head to head
UCB announced positive results from the Phase 3b BE RADIANT study, a direct comparison of the investigational IL-17A and IL-17F inhibitor, bimekizumab, to the IL-17A inhibitor, Cosentyx (secukinumab) in the treatment of adult patients with moderate-to-severe plaque psoriasis.1 BE RADIANT is the first head-to-head study comparing anti-IL-17 treatments, and the first study to demonstrate superiority to secukinumab for complete skin clearance at both weeks 16 and 48.
BE RADIANT met its primary endpoint at week 16 with statistical significance, demonstrating the superiority of bimekizumab over secukinumab for complete skin clearance, as measured by a 100 percent improvement in the Psoriasis Area and Severity Index (PASI 100) read more here
Mirikizumab superior to Cosentyx in phase 3 study
Eli Lilly the makers of Taltz, announced today that mirikizumab, an investigational monoclonal antibody that binds to the p19-subunit of IL23, met the primary and all key secondary endpoints versus placebo at Week 16 (superiority) and all key secondary endpoints versus Cosentyx (secukinumab) at Week 16 (non-inferiority) and Week 52 (superiority) in the OASIS-2 study. OASIS-2 is a multicenter randomized, double-blind, placebo-controlled study comparing the efficacy and safety of mirikizumab to placebo and Cosentyx in patients with moderate to severe plaque psoriasis.
The safety profile was consistent with previously disclosed results for mirikizumab and known safety findings of other drugs in the IL23p19 class.
"The results from this study are promising to people around the world who are burdened by psoriasis and Lilly is grateful to the patients, providers and investigators for advancing science to benefit patients with immunologic conditions," said Patrik Jonsson, senior vice president and president of Lilly Bio-Medicines. "We look forward to bringing mirikizumab to market to provide patients with an additional treatment option that has the potential to provide near complete or complete skin clearance as measured by PASI 90 and PASI 100, with sustained results at 52 weeks." read more here
basement asks about Development to Nytrile/Elastic gloves
Hello - let me give a brief history. Been in the Semiconductor field for 20years and am required to wear either nylon or nytrile gloves, sometimes with a cotton/elastic liner.
Developed a 'rash' in the past 3 months. Started on the wrist then spread across the tender area of both hands between fingers/top of hands. I call it a rash but it is more like very tiny blisters that will weep a clear slippery fluid. And of course, very itchy and burning. Eventually the blisters open and go away then left with dry and splitting skin.
One thought is that it could be a reaction to my own sweat, the cotton liners become saturated quickly depending on activity. I am trying to change the cloth liner more often, to keep a dry barrier against my hands. More here
A lot of members only threads and journals have been updated, come and see if there are more replies on your thread ... why not log-in and have a quick look around.
*There are other members only boards. But as it depends on how many posts you have made and what group you are in I won't add them here. The only way to see them is to make more posts.
Welcome to music with KatT. Where you can test your music knowledge and see/listen to other member's recommendations
Music Quiz: Score 1 point for each correct answer. This should be another easy one!
What is the song and the artist of the lyrics below? (multiple choice)Lyrics:
If you would like to leave some feedback you can post in the Newsletter thread Here
Right folks get your tackle out . . . . . .
We’re goin’ fishin’
Go bag yourself a nice fat Sea Bass
This month's recipe is dead simple in season and really tasty.
So if we are lucky Jim or Dave could nab us some Bass from the local fishermen and we can raid Poly for Fred’s Beans and Sun-dried Toms.
This will serve two as a good lunch or a light dinner
Start of by chopping around 70grams of chorizo into cubes and fry off in a frying pan over a medium heat for around 4 minutes, just until the oil starts to dribble out.
Grab an equal quantity of bread, a good sour-dough is best, a handful of parsley, the zest of a lemon and a nice fat clove of garlic. Throw the lot into a food processor and blitz the lot to a nice crumb.
Set your oven to around 190ºC / 370F / Gas 4/5. Lightly oil a sheet of baking paper on a baking tray and place two nice fillets on, skin side down. Cover the fish with the crumb mix making sure it is nicely stuck to the fish. It wants baking for 10 to 12 minutes.
For the green beans, here I’m talking the round things that are around 6mm in diameter and 130mm or so long topped and tailed. In a pan of boiling salted water blanch a big handful of your beans for around 4 minutes until just tender. Drain the beans and refresh with cold water.
In a frying pan over a medium heat drizzle a little of your favourite oil and fry off a finely sliced clove of garlic for 2 or 3 minutes – Don’t let it burn or it will go bitter**. Then you throw in the Green beans and around 50 grams of Sun Dried Tomatoes cooking for another 4 minutes or so.
Carefully remove the fish and its crumb coat from the baking tray and plate up with the beans.
To serve with . . . now I think you would need something nice, light, white and bright to run with this so I think a nice chilled Chenin Blanc or possibly a Pinot Grigio would do perfectly.
Sorry folks no snap to share again - I’ve sacked my paparazzi photographer recently.
** Right now its whinge time. Garlic. Please - where on Gods green earth can you get garlic that actually has some flavour these days. The stuff by us is bloody rubbish, no matter where we get it from. Once upon a time a recipe would call for a clove of garlic, you could basically wave the clove over the top of the dish and that would impart more than enough of that garlicky yummyness that not even your best friend would stand down wind of you the following day. Now I can put a full crushed bulb in and barely taste the thing. Why do they always breed the taste out of everything? Tasteless garlic takes just as long as tasty garlic to grow.
To read more recipes or add your own Click here
I'm always pleased when members submit photos for use in the newsletter and each month our members can choose 1 image to show on the newsletter and I'm always pleased to add them. This months theme is Wood
* All images are property of the member mentioned below the image.
See more members photos Here
Please remember no posts and no log-in for 12 months, your account will be deleted. For more information about this policy See Here!
Injections: They are only under the skin and although a bit daunting at first you soon get used to them. Remove from the fridge 20 minutes before use to help stop the slight stinging sensation.
Clothing: Always wear 100% cotton clothes; ie, t-shirts, trousers, underwear etc. Avoid polyester, nylon etc because they will irritate your skin.
Under arm deodorant: Make sure that your deodorant contains no alcohol.
Moisturiser: Use raw virgin coconut oil it has natural healing properties in it too.
Instant relief: Keep a bottle of your favourite moisturiser in the fridge. The cooling really helps with the irritation.
You’re not alone: People all around have it too they might just be good at hiding it.
Anti histamine: Use a supermarket own brand non-drowsey anti histamine to help with the itching. (Always read the instructions before taking)
Frozen peas: For a quick relief from the dreaded itch try a bag of frozen peas, hold it on the itchy zone for a couple of minutes.
To see the full list of top tips Or if you have one to share Click Here
Turnedlights poetry corner
I like to go down to the sea
Washed clean by the sound
And set free
I like to go down to the shore
A while to be lashed by the wind
I like to make peace on the beach
The deep state of calm
That we seek
Are yearning for down by the sea .
To read more poems or add your own Click Here
To see more thoughts of the day Click Here
This is proving a popular addition to the clubs off topic section
CERTIFIED COVID-19 FREE ZONE
Why not come on over and have a virtual coffee and slice of cake . Here's a place you don't need to keep your distance and can come and sit around one of our virtual tables for a chat, no masks necessary
Click Here to enter
Here are a few random quotes from members of Psoriasis Club, they are taken from posts that are visible to the public and are all unsolicited.
"Thank goodness for people like you and forums like this - Imapsomom"
"I really appreciate having this forum - Hawklight"
"I am so happy to find a support group where everyone truly cares. - SadieMae1"
"Y'all are so awesome with all the feedback. I don't feel so alone anymore. - SnarkyTexan"
"Thanks to all the persons of this great forum - sunnyman"
"Thanks for the warm welcome - KatT"
For more random quotes Click Here
Psoriasis Club is self funded, we don't rely on sponsorship or donations. We offer a safe friendly forum and are proactive against spammers, trolls, and cyberbullying. Join us here!
First Of Last
Caroline with M
Active Member Count
KatT with 963
Jiml with 2150
Raxyl with You have to pull the bowstring back Robin, I can't do everything for you
If you would like to take part in the next round or have a suggestion for a quiz See Here