Welcome to your November newsletter.
As I wake to a grey November morning, I'm wondering where this month will take us all. October started full of promise and there was hope that the covid numbers may start to drop but sadly we are almost back to where we started and most world governments are pumping money into economies in the hope of a bounce back and yet still people are facing hardship. We are almost 12 months into the pandemic and still there are those out there that won't obey rules so we will struggle to get it under control. Let's hope for a breakthrough with a vaccine soon so life can resume to some sort of normality. But the good news for psoriasis sufferers is that a new biological treatment is being trialed for psoriasis and Covid-19. More about that later in the newsletter.
I do hope your psoriasis is under control and your treatment is working. There have been a few advances in treatments with new drugs coming on stream for both psoriasis and psoriatic arthritis....if you are struggling with a treatment why not pop in and see what's new in treatments as it could help you when you're next with a dermatologist. Telling them what you think might be a good next option, or at least know about whatever it is they are suggesting.
So pop in and have a read Prescribed Treatments
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Dermavant to present phase 3 results of Tapinarof creams
Tapinarof is a potential first-in-class, steroid-free, cosmetically elegant, once-daily therapeutic aryl hydrocarbon receptor modulating agent (TAMA) topical cream being developed for the treatment of plaque psoriasis and atopic dermatitis. To date, over 2,200 subjects have enrolled in 18 clinical trials of tapinarof.
Dermavant Sciences, a clinical-stage biopharmaceutical company dedicated to developing and commercializing innovative therapeutics in immuno-dermatology, today announced that two posters on tapinarof will be presented during the upcoming 2020 Fall Clinical Dermatology Conference to be held virtually Oct. 29-Nov. 1, 2020. The two presentations will cover data from Dermavant’s successful Phase 3 PSOARING pivotal trials in addition to a maximal use pharmacokinetics study. Read more here
Tremfya (guselkumab) gets positive opinion from(CHMP) for psoriatic arthritis in the EU.
Janssen announced today that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion recommending the expanded use of TREMFYA (guselkumab) for the treatment of adult patients with active psoriatic arthritis (PsA) in the European Union (EU). Guselkumab is currently approved in the EU for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy. read more here
EDP1815 for psoriasis starts first patients on phase 2 trials
EDP1815 is an investigational oral biologic in development for the treatment of inflammatory diseases including psoriasis, atopic dermatitis, and COVID-19.
Evelo Biosciences, Inc a clinical stage biotechnology company developing a new modality of orally delivered, systemically acting biologics, today announced that it has dosed the first patients in its Phase 2 clinical trial evaluating EDP1815 for the treatment of mild to moderate psoriasis. EDP1815 is an investigational oral biologic in development for the treatment of inflammatory diseases including psoriasis, atopic dermatitis, and COVID-19. Read more here
AnaptysBio publish phase 2 data on imsidolimab for the treatment of generalized pustular psoriasis (GPP)
AnaptysBio, Inc a clinical-stage biotechnology company developing first-in-class antibody product candidates focused on emerging immune control mechanisms applicable to inflammation and immuno-oncology indications, today announced positive topline data from an interim analysis of its Phase 2 clinical trial of imsidolimab for the treatment of moderate-to-severe generalized pustular psoriasis (GPP), also known as the GALLOP trial. GPP is a chronic, life-threatening, rare inflammatory disease with no approved therapies.
“We are encouraged by the rapid onset, overall safety and promising efficacy profile demonstrated to date by imsidolimab for the treatment of patients suffering with GPP,” said Paul F. Lizzul, chief medical officer of AnaptysBio. “We look forward to engaging with regulatory authorities to progress imsidolimab into Phase 3, and in doing so offer a potential therapeutic intervention for these patients with high unmet medical need.” read more here
Illumya /Ilumetri time to relapse after withdrawal
This study says when treatment is interrupted, Ilumya / Ilumetri (tildrakizumab) provides durable maintenance of five to six months.
As treatment interruptions occur during psoriasis management in clinical practice, it is important to know the duration of clinical response after treatment withdrawal.
To report time to and predictors of relapse in patients who were tildrakizumab 100 and 200 mg responders (≥75% improvement in Psoriasis Area and Severity Index; PASI 75) at week 28 re‐randomized to placebo from reSURFACE 1 trial..... read more here
Psoriasis and bullous pemphigoid study
This study looked at psoriasis patients and bullous pemphigoid (BP) a rare skin condition that causes itching, redness and blisters.
Although the association of bullous pemphigoid (BP) and psoriasis is well‐established, the clinical and immunological features of patients with coexisting BP and psoriasis are yet to be investigated.
We aimed to estimate the prevalence of psoriasis among patients with BP and to elucidate the clinical and immunological characteristics of BP patients with comorbid psoriasis. To read more ...Click here
Visrael22 writes "my life with pustular psoriasis"
Hi, when I 1st developed Pustular Psoriasis in 2002 through 2003 was the worst time of my life. My left hand and foot worst case possible. The pain with pustular is unforgiving. Since the skin is shedding every 4 days to the normal of 28 days..in a 4 day period I maybe got 3 or 4 hours of relief. When patients talk about flare up's, pustular is a non-stop flare up. You name it..I did it. Creams made it worst and so did uv lights and laser. I was on stelara, which I had to check my liver function every 30 days..no relief and I stopped it. I sold my home in 2003 and rented a hotel on the beach for a month because my new house that I was having built wasn't ready. I sent my 2 children and my 90 year old father-in-law to stay with my mom. In 2 weeks I was clear of the most horrible thing I ever went through. It is stress related. My kids were teens and my father-in-law was a lot to care for. Now in 2020 with all we are going through with covid-19, ....... More here
CourtneyB asked about Taltz my first injection
Hi all, I was wondering if anyone can help me with a few questions regarding my first injection of Taltz. I took my first injection last night (administered by my friend who is a nurse) I my stomach. It is the pen and we did let it sit out to get to room temperature. I can handle the pain of the injection no problem. But right after it almost felt like I had pulled a muscle in my upper thigh area and I was walking with a limp. After waking up today, my lower back and hip are so tight that it hurts to barely move my right leg.
A lot of members only threads and journals have been updated, come and see if there are more replies on your thread ... why not log-in and have a quick look around.
*There are other members only boards. But as it depends on how many posts you have made and what group you are in I won't add them here. The only way to see them is to make more posts.
Welcome to music with KatT: Where you can test your knowledge on music and see other member's music recommendation!
Music Quiz: Score 1 point for each correct answer.
Can you match the number 1 hit song with the artist? (multiple choice)
#1: Bridge Over Troubled Water (1970) #A: Rihanna
#2: Don`t Go Breaking My Heart (1976) #B: Coldplay
#3: Maggie May (1971) #C: The Beatles
#4: Down Under (1983) #D: Elton John and Kiki Dee
#5: (Everything I Do) I Do It for You (1991) #E: Men At Work
#6: Viva la Vida (2008) #F: Rod Stewart
#7: Umbrella (2007) #G: Black Eyed Peas
#8: MMMBop (1992) #H: Brian Adams
#9: I Gotta Feeling (2009) #I: Simon and Garfunkel
#10: We Can Work It Out (1967) #J: Hanson
Note: Kat's recommendation ''Grandpa Voted Democrat'' by Ray Stevens was not on Deezer. The version on Deezer is by Matt Cline. Ray Stevens's version on Spotify is better. In addition, DFoster's recommendation ''The Storm'' by Eminem is only available on YouTube
If you would like to leave some feedback you can post in the Newsletter thread Here
Wow! November already. Where on earth did that come from?
Over here, in jolly old Britain, we celebrate the failed attempt of the assassination in 1605 of King James I and his Parliament lead by Robert Catesby. How one of the rest of the gang, a certain Guy Fawkes came to the fore and predominant in infamy I have no clue. But come every 5th November we celebrate with an effigy of Guy (generally a load of old stuffed clothes to the shape of a body) sat atop a large bonfire and copious quantities of Fireworks. There are also several ‘seasonal’ treats that appear around now so I thought I would break from the normal foodie recipe and do something a bit different. This is one of my favourites.
Treacle Toffee aka Bonfire Toffee
For those that don’t know Treacle is a thick black syrup that is the by product of cane sugar production, the leftovers from the boiling to produce the crystallised sugars. It's also known as blackstrap molasses in the Sates or just molasses.
So pull together the following goodies;
1lb / 450g Demerara Sugar (white will do at a push but the brown gives it a better flavour)
½lb / 225g Black Treacle
3oz / 85g Margarine (I will allow its use here)
¼ teaspoon Cream of Tartar (potassium bitartrate)
4 Tablespoons Water
1 Tablespoon Vinegar (Malt/white or white wine – it doesn’t matter)
I have made this once – DON’T use your best non stick pan. It might not end well. I made mine in a stainless pan and it went a bit wrong. It ‘caught’ and burned a nice layer in to the pan. It took me two hours to recover it. Tons of boiling water and lots of elbow grease.
The treacle can be a bit stubborn taking it out of the tin, stick the tin in some hot water for several minutes before starting.
In your pan dissolve the sugar into the water over a low heat then add the cream of tartar, then the margarine the treacle and the vinegar.
Bring it all to a boil and cook for around eight minutes. Just keep stirring it or it will stick – guaranteed. After your eight minutes to check that it's done take a little bit of it and drop it into some cold water. Once a drop sets hard and brittle it's done.
Pour the lot into a tray lined with baking parchment (so you can extract it afterwards) so its about 15mm thick is best and let it cool.
Once its cold take a rolling pin to it and shatter it into nice sized chunks. Its best kept in an airtight container or it will quickly congeal into a horrible mass. Just think of those toffees the kids have left in the door pocket in the car and you have just found them – yeah its worse!
Just a word of warning. For all of you with dental insurance – increase your payments. This stuff is one of the best ways of finding those fillings that are past their best. It will find them and rip them out without hesitation.
To read more recipes or add your own Click here
I'm always pleased when members submit photos for use in the newsletter and each month our members can choose 1 image to show on the newsletter and I'm always pleased to add them. This months theme is Autumn /Fall
* All images are property of the member mentioned below the image.
See more members photos Here
Please remember no posts and no log-in for 12 months, your account will be deleted. For more information about this policy See Here!
These members have a birthday this month showing in their profile. Maybe you would like to send them a PM on their special day
29th November AmandaL
Happy Birthday to you.
What to do with unwanted medications
We are often asked on the forum "Can I sell or give away my unused medication."
We all know how expensive the medications are and especially the biological injections and it seems a waste to leave them on the shelf when we feel someone else may be in need of them.
The law in most if not all countries state it is illegal to either give away or sell unused prescription drugs. It may seem unreasonable if you have been told to stop taking a drug and you still have unused sealed boxes.
You should dispose of them safely by taking them to your local pharmacy who will destroy them as they cannot be re-sold ..You should not put them in your domestic waste.
A Doctor was addressing a large audience at a conference
'The Material we put into our stomachs is enough to have killed most of us sitting here years ago.
Red meat is awful. Soft drinks corrode your stomach lining..
Chinese food is loaded with MSG. High fat diets can be disastrous,
and none of us realizes the long-term harm caused by the germs in our drinking water.
However, there is one thing that is the most dangerous of all and we all have eaten, or will eat it.....
Can anyone here tell me what food it is that causes the most grief and suffering for years after eating it?
After several seconds of quiet, a 75-year-old man in the front row raised his hand, and softly said
You can read more jokes here HERE
Turnedlights poetry corner
One thousand whispers
Grow and fade
They bathe in honeyed light
One thousand palms reach up
One thousand rays of life
The sun anoints
Those turned to face the skies
Until they blush
And slip away
One thousand voiceless sighs
The tone now grey
No more to say
The empty branches lift
And down below
They whisper still
One thousand bodies drift
To read more poems or add your own Click Here
To see more thoughts of the day Click Here
Here are a few random quotes from members of Psoriasis Club, they are taken from posts that are visible to the public and are all unsolicited.
"I feel better for being able to talk to people on here who are going through the same thing. - Sophiedophie"
"I've not long joined and I've never had such a warm welcome from anywhere else. - Susie"
"There's also lots of cheerful bits that I guarantee will put a smile on your face. - Lady B"
"Welcome to the forum! This forum maybe a small community, but lot's of great info. - mataribot"
"I have found the forum most informative and a great place to come for advice, and quite often just for a chuckle - jiml"
"The thing that helped me most with this site was the technical and personal information. - LL"
"Thank goodness for people like you and forums like this - Imapsomom"
"I am so happy to find a support group where everyone truly cares. - SadieMae1"
"Y'all are so awesome with all the feedback. I don't feel so alone anymore. - SnarkyTexan"
"Thanks for the warm welcome - KatT"
For more random quotes Click Here
Psoriasis Club is self funded, we don't rely on sponsorship or donations. We offer a safe friendly forum and are proactive against spammers, trolls, and cyberbullying. Join us here!
First Of Last
wooleyb with L
Active Member Count
Jiml with 965
Raxyl with 1888
wolleyb with B2
KatT with "Who's the tall idiot who designed this laundromat room"
If you would like to take part in the next round or have a suggestion for a quiz See Here