Psoriasis Club Newsletter

November 2020

Welcome to your November newsletter.

As I wake to a grey November morning, I'm wondering where this month will take us all. October started full of promise and there was hope that the covid numbers may start to drop but sadly we are almost back to where we started and most world governments are pumping money into economies in the hope of a bounce back and yet still people are facing hardship. We are almost 12 months into the pandemic and still there are those out there that won't obey rules so we will struggle to get it under control. Let's hope for a breakthrough with a vaccine soon so life can resume to some sort of normality. But the good news for psoriasis sufferers is that a new biological treatment is being trialed for psoriasis and Covid-19. More about that later in the newsletter.

I do hope your psoriasis is under control and your treatment is working. There have been a few advances in treatments with new drugs coming on stream for both psoriasis and psoriatic arthritis....if you are struggling with a treatment why not pop in and see what's new in treatments as it could help you when you're next with a dermatologist. Telling them what you think might be a good next option, or at least know about whatever it is they are suggesting.

So pop in and have a read Prescribed Treatments

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Psoriasis News and other related items

Dermavant to present phase 3 results of Tapinarof creams

Tapinarof is a potential first-in-class, steroid-free, cosmetically elegant, once-daily therapeutic aryl hydrocarbon receptor modulating agent (TAMA) topical cream being developed for the treatment of plaque psoriasis and atopic dermatitis. To date, over 2,200 subjects have enrolled in 18 clinical trials of tapinarof.

Quote:
Dermavant Sciences, a clinical-stage biopharmaceutical company dedicated to developing and commercializing innovative therapeutics in immuno-dermatology, today announced that two posters on tapinarof will be presented during the upcoming 2020 Fall Clinical Dermatology Conference to be held virtually Oct. 29-Nov. 1, 2020. The two presentations will cover data from Dermavant’s successful Phase 3 PSOARING pivotal trials in addition to a maximal use pharmacokinetics study. Read more here

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Tremfya (guselkumab) gets positive opinion from(CHMP) for psoriatic arthritis in the EU.

Quote:
Janssen announced today that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion recommending the expanded use of TREMFYA (guselkumab) for the treatment of adult patients with active psoriatic arthritis (PsA) in the European Union (EU). Guselkumab is currently approved in the EU for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy. read more here

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EDP1815 for psoriasis starts first patients on phase 2 trials

EDP1815 is an investigational oral biologic in development for the treatment of inflammatory diseases including psoriasis, atopic dermatitis, and COVID-19.

Quote:
Evelo Biosciences, Inc a clinical stage biotechnology company developing a new modality of orally delivered, systemically acting biologics, today announced that it has dosed the first patients in its Phase 2 clinical trial evaluating EDP1815 for the treatment of mild to moderate psoriasis. EDP1815 is an investigational oral biologic in development for the treatment of inflammatory diseases including psoriasis, atopic dermatitis, and COVID-19. Read more here

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AnaptysBio publish phase 2 data on imsidolimab for the treatment of generalized pustular psoriasis (GPP)

AnaptysBio, Inc a clinical-stage biotechnology company developing first-in-class antibody product candidates focused on emerging immune control mechanisms applicable to inflammation and immuno-oncology indications, today announced positive topline data from an interim analysis of its Phase 2 clinical trial of imsidolimab for the treatment of moderate-to-severe generalized pustular psoriasis (GPP), also known as the GALLOP trial. GPP is a chronic, life-threatening, rare inflammatory disease with no approved therapies.

“We are encouraged by the rapid onset, overall safety and promising efficacy profile demonstrated to date by imsidolimab for the treatment of patients suffering with GPP,” said Paul F. Lizzul, chief medical officer of AnaptysBio. “We look forward to engaging with regulatory authorities to progress imsidolimab into Phase 3, and in doing so offer a potential therapeutic intervention for these patients with high unmet medical need.” read more here

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Illumya /Ilumetri time to relapse after withdrawal

This study says when treatment is interrupted, Ilumya / Ilumetri (tildrakizumab) provides durable maintenance of five to six months.

Quote:
As treatment interruptions occur during psoriasis management in clinical practice, it is important to know the duration of clinical response after treatment withdrawal.

The objective...
To report time to and predictors of relapse in patients who were tildrakizumab 100 and 200 mg responders (≥75% improvement in Psoriasis Area and Severity Index; PASI 75) at week 28 re‐randomized to placebo from reSURFACE 1 trial..... read more here

Psoriasis and bullous pemphigoid study

This study looked at psoriasis patients and bullous pemphigoid (BP) a rare skin condition that causes itching, redness and blisters.

Quote:
Although the association of bullous pemphigoid (BP) and psoriasis is well‐established, the clinical and immunological features of patients with coexisting BP and psoriasis are yet to be investigated.

We aimed to estimate the prevalence of psoriasis among patients with BP and to elucidate the clinical and immunological characteristics of BP patients with comorbid psoriasis. To read more ...Click here

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Members treatments, questions and comments

Visrael22 writes "my life with pustular psoriasis"

Hi, when I 1st developed Pustular Psoriasis in 2002 through 2003 was the worst time of my life. My left hand and foot worst case possible. The pain with pustular is unforgiving. Since the skin is shedding every 4 days to the normal of 28 days..in a 4 day period I maybe got 3 or 4 hours of relief. When patients talk about flare up's, pustular is a non-stop flare up. You name it..I did it. Creams made it worst and so did uv lights and laser. I was on stelara, which I had to check my liver function every 30 days..no relief and I stopped it. I sold my home in 2003 and rented a hotel on the beach for a month because my new house that I was having built wasn't ready. I sent my 2 children and my 90 year old father-in-law to stay with my mom. In 2 weeks I was clear of the most horrible thing I ever went through. It is stress related. My kids were teens and my father-in-law was a lot to care for. Now in 2020 with all we are going through with covid-19, ....... More here

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CourtneyB asked about Taltz my first injection

Hi all, I was wondering if anyone can help me with a few questions regarding my first injection of Taltz. I took my first injection last night (administered by my friend who is a nurse) I my stomach. It is the pen and we did let it sit out to get to room temperature. I can handle the pain of the injection no problem. But right after it almost felt like I had pulled a muscle in my upper thigh area and I was walking with a limp. After waking up today, my lower back and hip are so tight that it hurts to barely move my right leg.

Read more here

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Want more?

Music with KatT

Welcome to music with KatT: Where you can test your knowledge on music and see other member's music recommendation!

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Music Quiz: Score 1 point for each correct answer.

Can you match the number 1 hit song with the artist? (multiple choice)

Song: Artist:

#1: Bridge Over Troubled Water (1970) #A: Rihanna

#2: Don`t Go Breaking My Heart (1976) #B: Coldplay

#3: Maggie May (1971) #C: The Beatles

#4: Down Under (1983) #D: Elton John and Kiki Dee

#5: (Everything I Do) I Do It for You (1991) #E: Men At Work

#6: Viva la Vida (2008) #F: Rod Stewart

#7: Umbrella (2007) #G: Black Eyed Peas

#8: MMMBop (1992) #H: Brian Adams

#9: I Gotta Feeling (2009) #I: Simon and Garfunkel

#10: We Can Work It Out (1967) #J: Hanson

Answers
1 goes with I
2 goes with D
3 goes with F
4 goes with E
5 goes with H
6 goes with B
7 goes with A
8 goes with J
9 goes with G
10 goes with C


Show Answers

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Members recommendations: Each month I ask our members to come up with a music recommendation on a theme. This month it's Politics.
Raxyl suggested: Native Tongue by Mo'Ju
Kat suggested: Grandpa Voted Democrat by Ray Stevens
Grizzly Bear suggested: Fortunate Son by Credence Clearwater Revival
jiml suggested: The Times They Are a Changing by Bob Dylan
wooleyb suggested: Land of The Free by The Killers
D Foster suggested: The Storm by Eminems
Caroline suggested: I Kissed a Girl by Katy Perry
JohnB suggested: Won't Get Fooled Again by The Who
Fred suggested: Give Ireland Back to The Irish by Paul McCartney & Wings
Mrs Fred suggested: Sunday Bloody Sunday by U2
KatT suggested: B.Y.O.B. by System of a Down

Listen on: Deezer | Spotify

Note: Kat's recommendation ''Grandpa Voted Democrat'' by Ray Stevens was not on Deezer. The version on Deezer is by Matt Cline. Ray Stevens's version on Spotify is better. In addition, DFoster's recommendation ''The Storm'' by Eminem is only available on YouTube

Show Recommendations

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If you would like to leave some feedback you can post in the Newsletter thread Here

Johnb's Recipe Spot

Treacle Toffee aka Bonfire Toffee

Wow! November already. Where on earth did that come from?

Over here, in jolly old Britain, we celebrate the failed attempt of the assassination in 1605 of King James I and his Parliament lead by Robert Catesby. How one of the rest of the gang, a certain Guy Fawkes came to the fore and predominant in infamy I have no clue. But come every 5th November we celebrate with an effigy of Guy (generally a load of old stuffed clothes to the shape of a body) sat atop a large bonfire and copious quantities of Fireworks. There are also several ‘seasonal’ treats that appear around now so I thought I would break from the normal foodie recipe and do something a bit different. This is one of my favourites.

Treacle Toffee aka Bonfire Toffee

For those that don’t know Treacle is a thick black syrup that is the by product of cane sugar production, the leftovers from the boiling to produce the crystallised sugars. It's also known as blackstrap molasses in the Sates or just molasses.

So pull together the following goodies;

1lb / 450g Demerara Sugar (white will do at a push but the brown gives it a better flavour)
½lb / 225g Black Treacle
3oz / 85g Margarine (I will allow its use here)
¼ teaspoon Cream of Tartar (potassium bitartrate)
4 Tablespoons Water
1 Tablespoon Vinegar (Malt/white or white wine – it doesn’t matter)

I have made this once – DON’T use your best non stick pan. It might not end well. I made mine in a stainless pan and it went a bit wrong. It ‘caught’ and burned a nice layer in to the pan. It took me two hours to recover it. Tons of boiling water and lots of elbow grease.

The treacle can be a bit stubborn taking it out of the tin, stick the tin in some hot water for several minutes before starting.

In your pan dissolve the sugar into the water over a low heat then add the cream of tartar, then the margarine the treacle and the vinegar.
Bring it all to a boil and cook for around eight minutes. Just keep stirring it or it will stick – guaranteed. After your eight minutes to check that it's done take a little bit of it and drop it into some cold water. Once a drop sets hard and brittle it's done.

Pour the lot into a tray lined with baking parchment (so you can extract it afterwards) so its about 15mm thick is best and let it cool.

Once its cold take a rolling pin to it and shatter it into nice sized chunks. Its best kept in an airtight container or it will quickly congeal into a horrible mass. Just think of those toffees the kids have left in the door pocket in the car and you have just found them – yeah its worse!

Just a word of warning. For all of you with dental insurance – increase your payments. This stuff is one of the best ways of finding those fillings that are past their best. It will find them and rip them out without hesitation.

Be warned

To read more recipes or add your own Click here

Members Photos

I'm always pleased when members submit photos for use in the newsletter and each month our members can choose 1 image to show on the newsletter and I'm always pleased to add them. This months theme is Autumn /Fall

Information

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